Endocrine Abstracts

Primary lymphomas of the thyroid are uncommon tumours, constituting fewer than 2% of all thyroid malignancies. For this reason their clinical features are not very well known. It seems that most of them arise in patients who have chronic autoimmune thyroiditis.From our patients with primary thyroid cancer since 1995, we selected those with pathological diagnosis of thyroid lymphoma. Epidemiological data, clinical features and response to treatment were a...

The mechanisms triggering autoimmunity in the Graves-Basedow disease (GBD) are unknown, although the evidence for a genetic predisposition is well established. The thyrotropin receptor (TSHR) is a good candidate gene.Objectives: To identify the main alleles/haplotypes of the TSHR gene, and to analyze the existence of TSHR susceptibility alleles to the GBD.Material and methods: To establish the main alleles of TSHR gene, 54 polymorp...

The ‘Multiple Endocrine Neoplasia’ predominantly affect the pituitary gland, parathyroids, thyroids, adrenal glands and pancreas. We present the case of a patient with three different functioning endocrine gland tumours, but who cannot be included in any of these groups.Case report: Sixty-five-years-old female with recurrent episodes of nephritic colic and hypertension for 2 years; non-specific gastrointestinal complaints, hirsutism, hyp...

Background: Familial non medullary thyroid carcinoma (FNMTC) is a not very well known histopatologic entity. Nowadays there are controversial publications about his aggresiveness and prognosisObjective: To know the clinical outcomes and histopathological characteristics of our patients with FNMTC and to compare them with a cohort of patients with sporadic non medullary thyroid carcinoma (CDT).Methods: We conducted a retrospective d...

IntroductionCurrent rise in use of monoclonal antibodies to Immune Check Point inhibitors (ICPIs) has led to the appearance of a great variety of immune-related adverse effects (irAEs), mainly affecting gastrointestinal tract, skin, liver and endocrinological system. With a variable prevalence (4–21%), thyroid dysfunction (TD) is the most common immune-mediated endocrinopathy. However, in the literature, it occurs in different patterns and levels of...

Background and aims: INSmutations can cause INS-MODy and have been described more frequently in cases of neonatal diabetes mellitus. The reported phenotypic expression of INS-MODy is quite variable.Objective: To clinically, biochemically and molecularly characterize INS-MODy patients in two Spanish tertiary level hospitals during the period 2009-2023.Methods: Cross-sectional study that included 121 pediatric patients with ...

Background: Inherited metabolic disorders (IMDs) are a group of heterogenous genetic disorders resulting in substrate accumulation, energy deficiency or complex molecular defects due to the failure of specific molecules to act as enzymes, cofactors, transporters, or receptors in specific metabolic pathways. The pathophysiological changes seen in IMDs sometimes impact on the endocrine system. We here describe our experience at one UK centre where patients are seen jointly by an...

RF-amide-related peptide-3 (RFRP-3), the mammalian orthologue of the avian gonadotropin-inhibiting hormone (GnIH), has been proposed as major inhibitory signal for the reproductive axis, acting via the NPFF1 receptor (NPFF1R). In addition, RFRP-3 has been recently suggested to modulate feeding, with reported orexigenic actions; a function that might contribute to the integrative control of energy homeostasis and reproduction. However, characterisation of the metabolic effects ...

While female fertility is known to be sensitive to conditions of low body fuel reserves, the reproductive consequences of persistent energy excess remain ill defined. Yet, the pandemic proportions of obesity, and its potential impact on the gonadotropic axis, call for a better understanding of this phenomenon. Alike, the influence of ovarian hormones on the pathophysiology of obesity and its complications merits further investigation. In this work, we aimed to elucidate the me...

Spanish Scientific Societies involved in diabetic patient care produced a consensus document with recommendations and quality indicators for hospital discharge reports (HDR).Objective: To analyse adequacy of HDR in diabetic patients from an Internal Medicine Service according to these recommendations (Med Clin (Bar) 2012 138 666.e1–666.e10).Methods: Study based on a programme continuity of care among ...